Hypoxia carbon monoxide-induced

Lactic acidosis Cyanide, carbon monoxide, ibuprofen, isoniazid, metformin, salicylates, valproic acid any drug-induced seizures, hypoxia, or hypotension... 

Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem 274 9038-9044. 

Tumor-associated or therapy-induced anemia can lead to a reduced O2 transport capacity of the blood, a major (systemic) factor contributing to the development of hypoxia (anemic hypoxia). This type of hypoxia is especially pronounced in tumors or tumor areas exhibiting low perfusion rates. A. similar condition can be caused by carboxyhemoglobin (HbCO) formation in heavy smokers, which leads to a functional anemia, since hemoglobin blocked by carbon monoxide (CO) is no longer capable of transporting oxygen. 

Huang, L.E., Willmore, W.G., Gu, J., Goldberg, M.A., and Bunn, H.F. (1999). Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J. Biol. Chem. 274, 9038-9044. 

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