Hypophysiotropic

Simpkins, J.W. (1983). Changes in hypothalamic hypophysiotropic hormones and neurotransmitters during aging. In J. Meites, ed., Neuroendocrinology of Aging. New York Plenum Press, pp. 41-59. 

Pease K, Shen H, Acres GS, Rupnow JH, Dixon JE (1980) Alterations in levels of thyrotrophin releasing hormone and rates of hormone degradation in hypothalamic tissue of the developing rat. J Endocrinol 85(1) 55—61 Queen G, Vivian S, LaBella F (1975) Monolayer cultures of dispersed cells from bovine anterior pituitary responses to synthetic hypophysiotropic peptides. Can J Physiol Pharmacol 53(6) 1094-8... 

Burgus, R., Dunn, T. F., Desiderio, D., Ward, D. N., Vale, W., Guillemin, R. (1970). Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor. Nature 226, 321-325. 

Guillemin R, Burgus R, Sakiz E, Ward DN. Further data on the purification of the TSH-hypophysiotropic hypothalamic hormone, TRF. Comptes rendus hebdomadaires des seances de... 

The neurons that elaborate hypophysiotropic hormones are themselves influenced by hypothalamic neurotransmitters, such as dopamine, norepinephrine, serotonin, acetylcholine, and endorphins. These neurotransmitters also modify the secretory activity of anterior pituitary hormones (see Table 50- i). Indeed basal and episodic secretion, diurnal rhythm, and nocturnal release of pituitary hormones are all considered to be secondary to central nervous system events that are mediated through hypothalamic hormones. 

Pohl, C.R., S.W. Richardson, J.S. Hutchison, J.A. Germak E. Knobil. 1983. Hypophysiotropic signal frequency and the functioning of the pituitary-ovarian system in the rhesus monkey. Endocrinology 112 2076-80. 

Our current knowledge of the functional relationships between the hypothalamus and the anterior pituitary gland is discussed in Chapter 4. The chemistry, actions and control of hypophysiotropic hormones are well covered. Much controversy exists over the value of copper complexes in the treatment of rheumatic disorders, although these compounds are active in many animal models of inflammation. Chapter 5 surveys this problem and should stimidate medicinal chemists to attempt the preparation of less toxic and more effective and stable complexes. 

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