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Hypomethylating agents

Some newly introduced pyrimidine analogs (e.g., azacitidine and decitabine) differ in their mechanism of action to such a degree from the other antimetabolites that they are subgrouped under the heading DNA de- or hypomethylating agents (see below). [Pg.147]

Azacytidine (Vidaza ) Hypomethylating agent Myelodysplastic syndrome Phase III... [Pg.447]

Decitabine (1) is a hypomethylating agent that exhibits potent antileukemic activity by inducing epigenetic changes in chromatin or reactivating tumor suppressor genes. It is administered intravenously at 15 mg/m2 over 3 h every 8 h for 3 consecutive days. The frequency of this administration is every 6 weeks. [Pg.50]

Issa J, Garcia-Manero G, Giles LJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2 -deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004 103 1635-1640. [Pg.2510]

Wijermans P, Liibbert M, Verhoef G, Bosly A, Ravoet C, Andre M, Ferrant A. Low-dose 5-aza-2 -deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome a multicenter phase II study in elderly patients. J Clin Oncol 2000 18(5) 956-62. [Pg.742]

Azacitidine is a DNA demethylation agent, that causes hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in bone marrow. Azacitidine is indicated in the treatment of myelodysplastic syndrome subtypes refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia. [Pg.95]

A recent report has shown that DNA hypomethylation may contribute to the induction of tumors in mice via an epigenetic mechanism causing chromosomal instability. In addition to facilitating neoplastic transformation, alterations in DNA methylation patterns have been shown to exert effects on embryonic development and acquired drag resistance to cytotoxic agents. Recent data from oiu laboratory have demonstrated the... [Pg.19]

See other pages where Hypomethylating agents is mentioned: [Pg.609]    [Pg.609]    [Pg.1494]    [Pg.506]    [Pg.449]    [Pg.417]    [Pg.732]    [Pg.736]    [Pg.609]    [Pg.609]    [Pg.22]    [Pg.197]    [Pg.609]    [Pg.609]    [Pg.1494]    [Pg.506]    [Pg.449]    [Pg.417]    [Pg.732]    [Pg.736]    [Pg.609]    [Pg.609]    [Pg.22]    [Pg.197]    [Pg.135]    [Pg.519]    [Pg.316]    [Pg.13]    [Pg.38]    [Pg.557]    [Pg.2388]    [Pg.135]    [Pg.327]   
See also in sourсe #XX -- [ Pg.729 ]



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Hypomethylation

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