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Hypolipidemic drugs enzyme induction

Fibrates (such as clofibrate) are hypolipidemic drugs. They cause a number of biological and biochemical effects, including enzyme induction, peroxisomal proliferation, liver hypertrophy and hyperplasia, and liver cancer. The mechanism is believed to be mediated through the PPARa receptor. Animals lacking this receptor do not show these effects. [Pg.435]

Following the discovery of peroxisomal long chain fatty acid P-oxidation in rat liver and its induction by hypolipidemic drugs, the involved enzymes were characterized mainly by Hashimoto, Osumi and coworkers in liver from induced rats. This resulted in the following picture. After activation, the CoA-esters are desatured by an FAD-dependent acyl-CoA oxidase. The formed 2-trans- noy -Cok is hydrated to a 3-L-hydrox-yacyl-CoA that is subsequently dehydrogenated to a 3-oxoacyl-(ToA. These reactions are... [Pg.261]

See other pages where Hypolipidemic drugs enzyme induction is mentioned: [Pg.177]    [Pg.280]    [Pg.197]    [Pg.165]    [Pg.1944]    [Pg.1948]    [Pg.85]   
See also in sourсe #XX -- [ Pg.177 ]



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