Hypnotics piperidinediones

Glutethimide (3-ethyl-3-phenyl-2,6-piperidinedione) is a sedative-hypnotic drug that is now rarely used therapeutically because of wide variation in gastrointestinal absorption, fast development of pharmacodynamic tolerance, a fairly severe discontinuation syndrome, and potential for abuse. Reports of... 

The chemical structures of some older and less commonly used sedative-hypnotics, including several barbiturates, are shown in Figure 22-3. Glutethimide (a piperidinedione) and meprobamate (a carbamate) are of distinctive chemical structure but are practically equivalent to barbiturates in their pharmacologic effects, and their clinical use is rapidly declining. The sedative-hypnotic class also includes compounds of simple chemical structure, including ethanol (see Chapter 23 The Alcohols), chloral hydrate, trichloroethanol, and paraldehyde (not shown). 

Therapeutic Function Sedative, Hypnotic Chemical Name 3-Ethyl-3-phenyl-2,6-piperidinedione Common Name 3-Ethyl-3-phenyl-2,6-dioxopiperidine Structural Formula ... 

Methyprylon. Interestingly, the two piperidinediones viz., glutethimide and methyprylon and the quinazolone viz., methaqualone, are of vital importance within the context of non-barbiturate sedatives and hypnotics. However, glutethimide and methyl prylon possess a striking resem-blanee to barbiturates as given below ... 

Therapeutic Function Sedative, hypnotic Chemical Name 3,3-diethyl-5-methyl-2,4-piperidinedione Common Name 2,4-dioxo-3,3-diethyl-5-methylpiperidine Structural Formula H... 

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