Hyperventilation, hypophosphatemia

Hypophosphatemia is associated with chronic alcoholism, parenteral nutrition with inadequate phosphate supplementation, chronic ingestion of antacids, diabetic ketoacidosis, and prolonged hyperventilation. 

The manifestations of hypophosphatemia depend on the chronicity and severity of the phosphate depletion. The major conditions associated with symptomatic hypophosphatemia are chronic alcoholism, intravenous hyperalimentation without adequate phosphate supplementation, and the chronic ingestion of antacids. Severe hypophosphatemia can also be seen during treatment of diabetic ketoacidosis and with prolonged hyperventilation. 

Conditions accompanied by hyperventilation (above normal respiratory rate and depth), such as diabetic ketoacidosis, sepsis (systemic infection), and alcohol withdrawal, result in a shift of phosphate out of the bloodstream into the cells, which, in turn, will cause hypophosphatemia. 

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