Hypertensive-adrenergic crisis, from

Hypertensive crisis MAO inhibitors with ingestion of tyramine containing food e.g. cheese, beer, red wine or fermented food can cause intracranial haemorrhage due to hypertensive crisis because of release of noradrenaline from adrenergic nerve endings by unmetabolised tyramine. 

Hypertension and tachycardia are the primary toxic manifestations of pseudoephedrine overdose. An amount of more than three or four times the maximum daily dosage for adults or children may produce symptoms of jS-adrenergic stimulation. In severe poisonings, cardiac dysrhythmias and cerebral hemorrhage due to hypertensive crisis may occur. Anxiety, muscle tremor, and seizures may result from CNS stimulation. Hallucinations, drowsiness, and/or irritability are more common symptoms exhibited by children. Hypokalemia and hyperglycemia may be noted. Acute renal failure and rhabdomyolysis have occurred in rare instances with large overdoses. 

Many foods and beverages (e.g., wine, cheese, and chocolate) contain tyramine. This chemical is normally degraded by MAOa, before systemic absorption. When the inhibition of MAOa occurs, due to the administration of these drugs, tyramine from ingested food is absorbed. It is then taken up into adrenergic neurons, where it enters the synthetic pathway and is converted to octopamine. a false transmitter. This results in a massive release of norepinephrine, and may result in a hypertensive crisis. 

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