Hypersensitivity syndrome olanzapine

Hypersensitivity syndrome, defined as a drug-induced complex consisting of fever, rash, and internal organ involvement, has been associated with olanzapine (243). 

Haematologic A case report of valproic add-related anticonvulsant hypersensitivity syndrome and subsequent olanzapine-related neutropenia and thrombocytopenia is described [177 ]. A case of a 23-year-old male who developed olanzapine-associated leucopenia and thrombocytopenia after a previous history of leucopenia with clozapine is reported [178 ]. 

Prevost P, Bedry R, Lacoste D, Ezzedine K, Haramburu F, Milpied B. Hypersensitivity syndrome with olanzapine confirmed by patch tests. Eur J Dermatol 2012 22(l) 126-7. 

A 27-year-old woman taking VPA and olanzapine developed a hypersensitivity syndrome consisting of diffuse rash with elevated liver enzymes, which resolved after VPA was discontinued. She subsequently developed neutropenia and thrombocytopenia. The authors suggested that both the hypersensitivity and the neutropenia/ thrombocytopenia may be due to drug interaction between VPA and olanzapine [197 ]. 

A Guillain-Barre-like syndrome has been associated with olanzapine hypersensitivity in a patient who already had an immunological disorder (244). 

Benito-Leon J, Mitchell AJ. Guillain-Barre-like syndrome associated with olanzapine hypersensitivity reaction. Clin Neuropharmacol 2005 28 150-1. 

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