Hyperprolactinemia case study

Endocrine A raised prolactin concentration occurs not uncommonly as an adverse effect of antipsychotic drugs but is less often associated with antidepressants. In a comprehensive review of case reports and prospective and retrospective studies, it was documented that all antidepressant classes, except mirtazapine, have been reported to cause hyperprolactinemia [2 ]. However, the findings were mostly derived from case reports and were inconsistent for individual agents within each antidepressant class. 

Endocrine New cases of hyperprolactinemia and galactorrhea have been reported [127, 128 ]. The correlation between risperidone plasma concentrations and prolactin plasma concentrations has been studied... 

Systematic reviews The efficacy of domperidone in diabetic gastroparesis has been evaluated in a systematic review of 28 clinical trials in a total of 1016 patients [7 ]. Domperidone improved symptoms, enhanced gastric emptying, and reduced hospital admissions in 60-70% of trials. None of the studies assessed the risk of adverse reactions to domperidone versus comparators. The most common adverse reaction was hyperprolactinemia, but in no case was it serious. 

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