Hypercompensation effect

This formulation is of advantage only when the constant ho (cq) is given a physical meaning (118, 119) or a supposed general linear relation between ho and /3—the so called hypercompensation effect (6)—is looked for (26, 102) or when it can be shown that ho is equal to zero (30,45, 172). Usually, or at least in kinetics, ho and Co are simply seen as intercepts without any special meaning and without a general relationship to Of course, eq. (11) can be written with interchanged variables, and in this case the intercept So can be interpreted as the so called model entropy (6). 

The P limitation causes a sharp decline of PolyPs in yeast cells (Liss and Langen, 1962 Kulaev and Vagabov, 1983). Under P limitation, yeast cells have often no31P NMR-visible PolyPs (Hofeler et al, 1987). When P,-starved yeast cells are placed on a complete medium, the PolyP content rises sharply, i.e. the so-called phosphate overplus (hypercompensation) effect occurs (Liss and Langen, 1962). 

In many organisms, the addition of P, to a culture previously deprived of phosphorus results in a rapid accumulation of PolyP to an extent many times exceeding the level which is characteristic of normal growth on a complete medium. This phenomenon is called hypercompensation or phosphate overplus . In E. coli, this effect was not found. The addition of P to a starved culture resulted in a rapid restoration of biomass accumulation. 

L. V. Trilisenko, N. A. Andreeva, T. V. Kulakovskaya, V. M. Vagabov and I. S. Kulaev (2003). Effect of inhibitors on polyphosphate metabolism in the yeast Saccharomyces cerevisiae under hypercompensation conditions. Biochemistry (Moscow), 68, 577-581. 

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