Hypercalcemia, thyrocalcitonin secretion

The effects of plasma constituents other than magnesium on the secretion of thyrocalcitonin, either as stimulants of secretion or as modifiers of the response of the gland to hypercalcemia, do not appear to have received much attention as yet. 

Apart from variations in the response of different animal species to thyrocalcitonin injections or infusions, already described, different species might vary widely in the degree of hypercalcemia necessary to stimulate secretion of thyrocalcitonin. Care et al. (C6) reported that hypercal-cemic perfusion of the sheep thyroid produced a hypocalcemic response similar in magnitude to that obtained by Foster et al. (F4) during hyper-calcemic perfusion of the thyroid and superior parathyroid in a goat of... 

Disturbances of calcium homeostasis have often been reported in diseases involving abnormal secretion of thyroid hormone. In thyrotoxicosis (G5, K2) the disturbance, if present, usually manifests itself as hypercalcemia of moderate degree, with loss of calcium from the bones and increased urinary output of calcium, thus suggesting a possible deficiency of thyrocalcitonin output in this type of thyroid disease. Most such observations antedate the discovery of thyrocalcitonin, and there is not yet much information on the response of such patients to an... 

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