Hyperbolic and Parabolic Inhibition

In Chapter 5, we have examined the properties of several simple linear types of inhibition systems. All these types have, in common, a dead-end El or a nonproductive EAI complex, or both. In order to introduce more complex cases of inhibition, we shall start with an analysis of nonlinear inhibition with less-demanding monosubstrate reactions (Cleland, 1970, 1977 Fromm, 1975). 

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In the hyperbolic and paraboUc types of inhibition, the family of straight Unes in the double reciprocal plot of i/uo versus 1/A (at different fixed concentrations of I) will have a corruBon intersection point only if the denominator (i+Z/ y terms are identical in slope and intercept terms. Usually this is not the case, that is, the K will be different in the denominator of the slope and intercept terms. There is not a crossover point if only slope or intercept is hyperbolic or parabolic and the other is Unear. 

In the preceding chapters, as well as in this chapter, we have encountered a number of different types of inhibitors. The inhibitors have been classified as competitive, uncompetitive, and noncompetitive. Further, the inhibition can be classified as hnear, parabolic, and hyperbolic. Further types of inhibition, which... 

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