5-Hydroxytryptamine subtypes

Baker LP, Nielsen MD, Impey S, et al. Stimulation of type 1 and type 8 Ca2+/ calmodulin-sensitive adenylyl cyclases by the Gs coupled 5-hydroxytryptamine subtype 5-HT7A receptor. J Biol Chem 1998 273 17,469-17,476. 

Serotoninergic System. Figure 1 Graphical representation of the current classification of 5-hydroxytryptamine (5-HT) receptors. Receptor subtypes represented by shaded boxes and lowercase designate receptors that have not been demonstrated to definitively function in native systems. Abbreviations 3-5r cyclic adenosine monophosphate (cAMP) phospholipase C (PLC) negative (-ve) positive (+ve)... 

Samanin, R and Grignaschi, G (1996) Role of 5-hydroxytryptamine receptor subtypes in satiety and animal models of eating disorders. In Drug Receptor Subtypes and Ingestive Behaviour (Eds Cooper, SJ and Clifton, PG), Academic Press, London, pp. 39-58. 

N-methyl-actinodaphnine possesses 5-hydroxytryptamine receptor blocking activity and a selective antagonist of cq-adrenoceptors, selective for the a1B. than for the a1A-adrenoceptor subtype (14). What are the activities of N-methyl-actinodaphnine and other aporphines of Illigera and Hernandia species against topoisomerase ... 

Dennis J. McKenna, David B. Repke, Leland Lo, and Stephen J. Peroutka. "Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes." Neuropharmacology 29 (1990) 193-98. 

Pharmacology Naratriptan, rizatriptan, sumatriptan, frovatriptan, almotriptan, eletriptan, and zolmitriptan are selective agonists for a vascular 5-hydroxytryptamine-i(serotonin) receptor subtype. Use of 5-HT- agonists results in... 

Serotonin (5-hydroxytryptamine 5-HT) acts as transmitter and mediator on several locations in the body with quite different effects. There are multiple sub-types of the serotonin receptor. This offers the possibility of a selective therapeutic interference using subtype specific agonists or antagonists. 

To date, the only serotonergic agonist that was associated with the provocation of brief exacerbations of OCD symptoms in some studies is mCPP, which possesses only weak affinity for dopamine, acetylcholine, and a,-adrenergic and (i-adrenergic receptors [Hamik and Peroutka 1989). The agonistic activity of mCPP is greatest for the 5-hydroxytryptamine [5-HT serotonin] S-HTjc and S-HTj receptor subtypes and to a lesser extent to the 5-HT, and 5-HTjp subtypes [Barr et al. 1992]. 

Most 5-hydroxytryptamine (5-HT, serotonin) pathways originate from neurons in the raphe or midline regions of the pons and upper brain stem. 5-HT is contained in unmyelinated fibers that diffusely innervate most regions of the CNS, but the density of the innervation varies. 5-HT acts on more than a dozen receptor subtypes. Except for the 5-HT3 receptor, all of these... 

GOthert M, Duhrsen U (1979) Effects of 5-hydroxytryptamine and related compounds on the sympathetic nerves of the rabbit heart. Naunyn Schmiedebergs Arch Pharmacol 308 9-18 Gotti C, Zoli M, Clementi F (2006) Brain nicotinic acetylcholine receptors native subtypes and their relevance. Trends Pharmacol Sci 27 482-91 Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP, McIntosh JM, Marks MJ, Collins AC (2001) Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus a function mediated by a different nAChR than dopamine release from striatum. J Neurochem 76 258-68... 

Saudou F, Hen R. 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem Int 1994 25 503-532. 

Serotonin or 5-hydroxytryptamine (5-HT) receptors with 7 subtypes and at least 15 distinct members mediate a diverse array of physiological functions both in the central nervous system and in the periphery (1). Their varied cellular distribution and complex signal transduction in part account... 

Serotonin (5-hydroxytryptamine [5-HT]) produces its effects through a variety of membrane-bound receptors, located in the central and peripheral nervous systems and in non-neuronal tissues in the gastrointestinal tract, cardiovascular system, and blood. The knowledge of the anatomical localization of the receptors is an important step forward for the understanding of their function. Several techniques allow the microscopic visualization of the sites of expression of these receptors in the tissues. In this review, we will attempt to summarize the available information on the neuroanatomical organization of each one of the 5-HT receptor subtypes. 

Dixit VD, Schaffer EM, Pyle RS, CoUins GD, Sakthivel SK, Palaniappan R, I.illaid JW, Taub DD (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J CUn Invest 114 57-66 Dmitrieva N, Shelton D, Rice ASC, McMahon SB (1997) The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78 449-459 Doak GJ, Sawynok J (1997) Formalin-induced nodceptive behavior and edema involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes. Neuroscience 80 939-949 Dobner PR (2006) Neurotensin and pain modulation. Peptides 27 2405-2414 Dobolyi A, Ueda H, Uchida H, Palkovits M, Usdin TB (2002) Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A 99 1651-1656... 

BIMU 1 is a benzimidazole-carboxamide derivative, a selective (S-HT -subtype) 5-hydroxytryptamine receptor AGONIST. It has antiemetic properties, and is used as a pharmacological tool. 

BMY 13805-1 MJ 13805) is one of the azaspirone group structurally related to buspirone and with similar properties. It is a 5-hydroxytryptamine receptor agonist, a partial agonist at the 5HTi receptor subtype. It is a novel ANXIOLYTIC under investigation for treatment of anxiety and depression. 

HT7 (5-HTx) receptors couple positively to the adenylyl cyclase (GJ system. There are no subtype selective agonists, but LSD is active here. See also 5-hydroxytryptamine... 

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