Hydroxypropyl-P-CD

The authors also studied the influence of the chain length of alkylmaltosides on the nasal absorption of enoxaparin. The results indicated that increases in the concentration of alkylmaltosides increased the AUC for plasma anti-factor Xa it was found that the absolute and relative bioavailabilities of enoxaparin increased by twofold with an increase in alkyl chain length from 8 to 14 carbons. Of all the alkylmaltosides, TDM was found to be the most potent absorption enhancer [85], Furthermore, we have also shown the efficacy of cyclodextrins in enhancing absorption following the nasal delivery of LMWHs. Three different cyclodextrins were employed P-cyclodextrins (P-CD), hydroxypropyl p-CD (FIPP-CD), and dimethyl P-CD (DM(5-CD). P-CD showed therapeutic levels of anti-factor Xa only at 2.5 and 5% p-CD, but there was no significant difference between the two concentrations, which was attributed to their solubility limit. In the case of HPP-CD, neither 1.25 nor 2.5% produced an appreciable increase in anti-factor Xa levels ... 

Hydroxy alkylation of p-CD requires treating base-solubilized p-CD with the appropriate epoxide or haloalcohol.f Propylene oxide or propylene carbonate are used in the preparation of 2-hydroxypropyl p-CD ((2HP)-p-CD), the derivative being commercialized. The reaction occurs at both primary and... 

Various excipients with parenteral use Hemolytic effects with rat blood (e.g., >1%-hydroxypropyl-P-CD, >2.5%-PEG 400, >5%-propylene glycol, >0.125%-Tween 80) May be related to high-concentration effect 60... 

Imazaquin enantiomers Sodium hydrogen phosphate (50 mM) at pH 10.1 containing 30 mM hydroxypropyl-P-CD (HP-P-CD) — [25]... 

Different cellulose-supported CD catalysts were used to assess their effectiveness for the oxidation process. CDs immobilized onto the cellulose were a-CD, p-CD, and 2-hydroxypropyl-p-CD (2-HP-p-CD). The amount of CDs immobilized onto the polymers was 0.18 mmol/g. The authors showed the importance of the CD cavity size, especially regarding the reaction yield. The a-CD-cellulose copolymer (cavity size of 5.2 A) gave benzaldehyde in 59%... 

Photo-induced polymerization of hydroxypropyl-P-CD/methyl methacrylate complex, i.e. HP-P-CD/MMA was performed in aqueous solution, at room temperature with Irgacure 2959, i.e. 4-(2-hydroxyethoxy)phenyl-(2-hydroxy-2-propyl)ketone serving as a photoinitiator [75]. The atom transfer radical polymerization (ATRP) and reversible addition fragmentation chain transfer (RAFT) [76] methods are also used to perform polymerization of the CD/guest monomer complexes in aqueous solutions. 

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