4-hydroxymethyl-2-phenyl

Optically active 5-(hydroxymethyl)-3-phenyl-2-isoxazoline 13 is a versatile key intermediate for the syntheses of /3-hydroxy ketones, y-amino alcohols,and y-amino acids. However, the Upase-catalyzed kinetic resolution of isoxazoline ( )-13 has not been reported so far probably because of the low enantioselectivity expected for primary alcohols (Scheme 3). The enantioselectivity was found to be very low E value = 4-5 in /-Pr20) at room temperature however, it could be markedly improved up to an value of 249 at —60°C by using lipase PS-C 11 in acetone, which was the best solvent among those tested (THF, /-Pt20) 1 )-... 

TABLE 6.3. 5-(HYDROXYMETHYL)-3-PHENYL-l//-l,2,4-TRIAZOLES EROM 2-PHENYE-4(5H)-OXAZOLONE AND HYDRAZINES"... 

OH HOOC c h2 - c h2 2-(2-Hydroxy-phenyl)-l-(2- hydroxymethyl-phenyl)-dthan 76 109,5 4... 

Hydroxymethyl-phenyl)- 227 Methoxy-phenyl- -oxim 487 (4-Methyl-phenyl)-... 

Hydroxymethyl-phenyl )-athyl]- 167 -(3-Hydroxy-propeny )- 228 -Jod-2-mcthoxy-5-(2-amino-l-hydroxy-athyl)- 118 Mercapto- 444 2-Mercapto-... 

Decomposition of salicin (2-(hydroxymethyl)phenyl-/ -D-glucopyranoside) yields two alcohols glucose (a compound with numerous 1°, 2°, and a 3° hydroxyl functionalities, Fig. 13.4.6) and l-0H-2-CH20H-benzene (a 1° alcohol, Fig. 13.4.7). Further oxidation of l-0H-2-CH20H-benzene leads to the formation of salicylic acid ... 

The pyrirnido[ 1,6-/z [3,l [benzoxazin-1 -thionc 230 was formed in a tandem [5+1, 6+0 (/ )] cyclization as depicted in Scheme 38. The first step is the nucleophilic attack of the aniline nitrogen of 228 (X = O) onto the isothiocyanate and then onto the aldehyde carbon to form l-(2-hydroxymethyl)phenyl-6-hydroxy-tetrahydropyrimidine-2-thione, which cyclizes to 230 <2005BMC3185>. 

Dihydro-6- [3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol +0.55 glassy carbon 264... 

Carbosilane dendrimer [G1] with 4-(hydroxymethyl)phenyl linker... 

A Pummerer rearrangement features in two approaches to 1,3-oxathiins. Refluxing y,8-unsaturated sulfinyl compounds (26) in xylene containing TsOH effects conversion to the 3,1-benzoxathiin (27) via a sulfonium ion intermediate (95CC1197), whilst 2-(hydroxymethyl)phenyl sulfoxides (28), readily cyclise to the benzoxathiin (95T6819). 

The syntheses of poly(CTTV) was accomplished by the polymerization of a 3,4-bis(n-alkyloxy)benzyl alcohol (130) with a a,w-bis [2-(al-kyloxy)-5-(hydroxymethyl)phenyl]oxy alkane (135) [76]. 

Biological Recognition of Enantiomeric Silanes and Germanes Syntheses and Antimuscarinic Properties of the Enantiomers of the Si/Ge Analogues Cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)silane and -Germane and Their Methiodides... 

Hydroxymethyl-phenyl)-methyl-E13/2, 1326 (S-Oxigenier.) (2-Methoxy-phenyl)-methyl- E13/2, 1325 (S-Oxigenier.)... 

H-Diazirin 3-(4-Hydroxymethyl-phenyl)-3-trifluormethyl- E16c, 719 (Ether-Spaltung)... 

Phenol 2-Trimethylsilyl- XIII/5, 42 Silan Dimethyl-hydroxymethyl-phenyl- XIII/5, 74... 

C13H15N302 pyrolan 87-47-8 25.00 1.2014 2 26241 Cl 3H1807 2-(hydroxymethyl)phenyl-beta-D-glucopyranosi 138-52-3 25.00 1.4340 1... 

Chloroacetophenone is quite stable. It is not hydrolysed by water even on boiling and it is unaffected by humidity. It is completely decomposed by 60% oleum. Hot aqueous solutions of sodium carbonate convert it into hydroxymethyl phenyl ketone of the formula (Graebe), CjHj—CO—CHjOH, which forms crystals melting at 86° C. and boiling at 118° C. at ii mm. mercury pressure. It is soluble in alcohol, ether and chloroform. 

Rod—coil molecules containing structurally perfect conjugated rods were synthesized by using a-(phen-yl)-ft -(hydroxymethyl phenyl)-poly(fluoren-2,7-ylene) as macroinitiator (Scheme 8).98 Anionic polymerization of ethylene oxide by using the macroinitiator produced a corresponding rod—coil block copolymer (22). The absorption and emission measurements of... 

Aus 2-(2-Hydroxymethyl-phenyl)-l,3-benzothiazol entsteht mit Phosphor(III)-bromid 11H-(Jsoindolio 1,2-b]-l, 3-benzothiazoliurri)-bromid (91% Schmp. 243—258°) 84,V8 385 ... 

Hydroxymethyl-phenyl)- 944 5-Hydroxymethyl-2-phenyl- 986 2-(2-Hydroxy-l-methyl-2-phenyl-ethyl)- 994 2-(l-Hydroxy-l-methyl-3-phenyl-2-propinyl)- 956 2-(5-Hydroxy-3-methyl-pyrazolo)- 487 2-(5-Hydroxy-l-methyl-lH-pyrazol-3-yl)- 987... 

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