Hydroxyl group position

The mutation of the hydroxyl group positioned in R-configuration at the C(3) atom of the central statine (rSta) residue of the inhibitor gives rise to AAGbind of -0.51 kcal/mol, which is very close to the experimental value of -0.8 kcal/mol. It may be noted here that the starting configuration of the inhibitor in the enzyme-inhibitor complex is the same as that of pepstatin. The crystal structure of rhizopus pepsin or any other aspartic proteinase... 

One or two of the primary hydroxyl groups (position 6) are used to link the cyclodextrin to the silica surface. The secondary hydroxyl groups (positions 2 and 3) can be derivatized selectively, usually first in position 2 and then subsequently in position 3. A number of different derivatives of the cyclodextrins have been synthesized to provide specific types of interaction to increase their chiral selectivity. 

In the series of simple fiavonoids, DE50 values provide information on the influence of hydroxyl group position, the presence of a ketone, and the rigidity of the skeleton with respect to the C2-C3 double bond (in the C-ring, see Figure 6.1). 

Modification of the structure of Neu/VAc continues apace. Routes to the 4-, 7- and 8-oxo- derivatives (as methyl glycosides) have been reported it was found that, using PCC, selective oxidation at C-4 was possible in the presence of a 7-hydroxyl group, positions 8 and 9 being protected as an isopropylidene group. Oxo compounds were also intermediates in the... 

Policosanol High-molecular-weight molecules of aliphatic alcohols with a hydroxyl group positioned at one of the terminal ends. The most common are octacosanol (28 carbons) and triacontanol (30 carbons). The policosanols are synthesized from short-chain or volatile fatty acids that are first reduced to aldehydes and then to alcohols. The maize germ and related coproducts obtained from dry- and wetmilling processes are the main source. The policosanols exert health benefits that include lowering blood cholesterol and preventing arteriosclerotic lesions. 

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