14-hydroxy reduction

Naltrexone (162), like naloxone, was more extensively metabolized after oral adminstration than following the parenteral route. Major metabolites in plasma, urine, and feces have been identified 459 by gc/ms as naltrexone-3-glucuronide and conjugated and unconjugated 6/3-hydroxy reduction product (270). The geometry at C-6 had been established during an earlier study. 460 Minor quantities of the C-2 oxidation product, 270, (R = OMe R = OH) and 270 (R = OMe, R = H) were also found. Oxycodone (44) gave the unusual 6/3,7/3-dihydroxy metabolite (271) in rabbits. 

Ceroplastol synthesis, 1, 428 Cetyl alcohol synthesis, 1, 478 Chaetoglobasins structures, 4, 376 Chalcone, o -azido-2 -oxy-synthesis, 3, 823 Chalcone, 2-hydroxy-reduction, 3, 751 Chalcone, 2 -hydroxy-mass spectra, 3, 618 Chalcone dibromides flavone synthesis from, 3, 823 Chalcones polymers, 1, 304 Chanoclavine synthesis, 6, 423 Charge density waves in stacks of ions, 1, 351-352 Chartreusin... 

Coumaranone-2-acetic add, 4,6-dimethyl-synthesis, 3, 850 /3-Coumaranones synthesis, 4, 710 Coumaric add synthesis, 3, 685 Coumarilic add deprotonation, 4, 81-82 synthesis, 4, 697 Coumarilic add, 4,6-dimethyl-deprotonation, 4, 81-82 Coumarin, 3-acyl-4-hydroxy-reduction, 3, 690 Coumarin, 4-alkoxy-IR spectra, 3, 596... 

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