Hydroxy octane

D° [Amin Oxiran 1 1] Zeolith ZCP-50/ Benzol, Ruckfl. 9 h [Amin Oxiran — 1 1] Zn-(2 J ,3 R)-tartrat/ CH2C12, 20-25% 7d 1 Anilino-2-hydroxy-octan + 2-Anilino-l-hydroxy-octan (-7 3) (1 R,2R)-2-Anilino-l-hydroxy-cyclohexan (ee 52 %) 90 28 3 4... 

Hydroxy- octan 5-Oxo-2-methyl-2-hexyl- 3-carboxy-tetra- hydrofuran 23 ... 

Pure citronellal is a colorless liquid with a refreshing odor, reminiscent of balm mint. Upon catalytic hydrogenation, citronellal yields dihydrocitronellal, citronellol, or dihydrocitronellol, depending on the reaction conditions. Protection of the aldehyde group, followed by addition of water to the double bond in the presence of mineral acids or ion-exchange resins results in formation of 3,7-dimethyl-7-hydroxy-octan-l-al (hydroxydihydrocitronellal). Acid-catalyzed cyclization to iso-pulegol is an important step in the synthesis of (-)-menthol. 

Further additions to the long list of tobacco constituents include 5(13),7 -megastigmadiene-6,9-diol (44), (3S,6i ,9i )-4,7 -megastigmadiene-3,9-diol (45) and its 95-epimer, and a seco-nor-carotenoid , 3,3-dimethyl-7-hydroxy-octan-2-one (46), all from Greek tobacco. The structures (47), (48), and (49) of pallescensin-1, -2, and -A have been proved by synthesis from a-cyclocitral (50)." ... 

Dimethyl-7-hydroxyoctanal 3,7-Dimethyl-7-hydroxyoctan-1 -al 3,7-Dimethyl-7-hydroxy-octane-1-al. See Hydroxycitronellal... 

Lilyl aldehyde Musuet synthetic Musuettine principle 1-Octanal, 3,7-dimethyl-7-hydroxy Octanal, 7-hydroxy-3,7-dimethyl-... 

Hydroxy-3-methylenetrldecan-2-one (2). A solution of decanal 1 (3.12 g, 20 mmol), methyl vinyl ketone 2 (1.4 g, 20 mmol) and 1,4-diazablcyclo-octane (DABCO) (0 33 g,... 

Chemical Name [3(S)-endo] -8-[(4-butoxyphenyl)methyl] -3-(3-hydroxy-1-oxo-2-phenyl-propoxy)-8-methyl-8-azoniabicyclo[3.2.1 ] octane bromide... 

Chemical Name 3-(3-Hydroxy-1 -oxo-2-phenylpropoxy)-8-methyl-8-(1 -methylethyl)-8-azoniabicydo[3.2.1 ]octane bromide... 

R,5R)-2-tert-butyl-5-[(R)-hydroxy( phenyl)minhyl -3-oxa-7-thia-t-a abkydo 3.3.0 octan-4-(me yield ca. 50%... 

The Postnitrated Polyurethane Polymer of 3,6-Dinitro-3,6-Diaza-1,8-Octane Diisocyanate with N,N -Bis (2-Hydroxy ethyl) Oxamide. 

Dioxo-4,8-diphenyl-l,3,5,7-tetraaza-bicyclof3.3.0]octan laBt sich durch Lithium-alanat in5-Hydroxy-3- phenyl-1,2,4- triazolidin (14% d.Th.), N-Methyl- benzylamin auf-spalten4 ... 

Hydroxy-tridecan-4-olid1 —> 8-Hydroxy-tetradecan-S-olid1 —> 3-Oxo-4,4-dimethyl-2-oxa-bicyclo[3.3.0]octans 45% d.Th. 

N H3c —COO H3C-COO It 0 K[BH4] 3-Hydroxy-8-methyl-trans-6,7-diacetoxy-8-aza-bicyclo[3.2.1]octan 84 3... 

As a first step in the prepartion of polymers patterned after the repeating unit of nonactin 56, Moore and Kelley53 synthesized 3,8-dioxabicyclo[3.2.1 ]octan-2-one 57 and its corresponding polyester 58. The monomer was prepared from 5-hydroxy-methylpyran-2-carboxylic acid in overall yield of 20%. It was heated with a catalytic amount of tert-butoxytitanate under nitrogen for 3 hr at 100 °C. The temperature... 

In the presence of a base such as l,4-diazabicyclo[2.2.2]octane (DABCO) or tri-alkylphosphines, conjugated carbonyl compounds such as esters and amides add to aldehydes via the a-carbon to give a-alkenyl-P-hydroxy esters or amides. This sequence is called the Baylis-Hillman reaction and a simple example is... 

CN e/jdo-( )-3-(3-hydroxy-l-oxo-2-phenylpropoxy)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane nitrate... 

Hydroxy-2-pentynoic acid, 56, 51 7-Hydroxy-4,4,5,7-tetramethylbicyclo-[4.2.0] octan-2-one, 57, 115 V-Hydroxy-l-(p-tolylsulfonyl)meth-animidoyl chloride, 57, 100 11-HYDROXYUNDECANOIC LACTONE, 58, 98, 100... 

The bicyclic silanol endo-3-methyl-exo-3-hydroxy-3-silabicyclo-[3.2.1]octane may be prepared by treating the corresponding methoxysi-lane with silica gel. Although the position of the OH hydrogen atom was found to be disordered 253), the intermolecular 0---0 distances of 2.69 and 2.71 A suggest that the molecules are joined into zigzag chains as shown in Fig. 8 210). 

Fig. 8. The hydrogen-bonded chain structure of endo-3-methyl-exo-3-hydroxy-3-silabicyclo[3.2.1]octane, with hydrogen atoms omitted for clarity. Drawn using coordinates taken from the Cambridge Crystallographic Database.

A common procedure in C-C-bond formation is the aldol addition of enolates derived from carboxylic acid derivatives with aldehydes to provide the anion of the [5-hydroxy carboxylic acid derivative. If one starts with an activated acid derivative, the formation of a [Mac lone can follow. This procedure has been used by the group of Taylor [137] for the first synthesis of the l-oxo-2-oxa-5-azaspiro[3.4]octane framework. Schick and coworkers have utilized the method for their assembly of key intermediates for the preparation of enzyme inhibitors of the tetrahydrolipstatin and tetrahydroesterastin type [138]. Romo and coworkers used a Mukaiyama aldol/lac-tonization sequence as a concise and direct route to 3-lactones of type 2-253, starting from different aldehydes 2-251 and readily available thiopyridylsilylketenes 2-252 (Scheme 2.60) [139]. 

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