5 -Hydroxy -2,2 -dimethyl -6 - chroman

H-Benzo[a]carbazole, 4,4a,5,l 1,1 la,l Ib-hexahydro-synthesis, 4, 283 Benzo[b]carbazole, N-acetyl-photochemical rearrangements, 4, 204 Benzo[/]chroman-4-one, 9-hydroxy-2,2-dimethyl-synthesis, 3, 851 Benzochromanones synthesis, 3, 850, 851, 855 Benzochromones synthesis, 3, 821 Benzocinnoline-N-imide ring expansion, 7, 255 Benzocinnolines synthesis, 2, 69, 75 UV, 2, 127 Benzocoumarins synthesis, 3, 810 Benzo[15]crown-5 potassium complex crystal stmcture, 7, 735 sodium complex crystal stmcture, 7, 735 Benzo[ 18]cr own-6 membrane transport and, 7, 756 Benzo[b]cyclohepta[d]furans synthesis, 4, 106 Benzocycloheptathi azoles synthesis, 5, 120... 

Chroman, 6-hydroxy-2,2-dimethyl- C NMR, 3, 587 Chroman, 2-hydroxymethylene-synthesis, 3, 781... 

Chroman-4-one, 5-acetoxy-3-hydroxy-2,2-dimethyl-synthesis, 3, 857 Chroman-4-one, 3-amino-synthesis, 3, 855 Chroman-4-one, 3-benzylidene-synthesis, 3, 829 Chroman-4-one, 3-bromo-... 

Chroman-4-one, 3-bromo-2-hydroxy-synthesis, 3, 856 Chroman-4-one, 2-/-butyl- H NMR, 3, 583 Chroman-4-one, 3-/-butyl- H NMR, 3, 583 Chroman-4-one, 2,3-dibromo-dehydrobromination, 3, 828 Chroman-4-one, 3,3-dibromo-dehydrobromination, 3, 828 Chroman-4-one, 2,3-dihalogeno-synthesis, 3, 856 Chroman-4-one, 2,2-dimethyl-mass spectra, 3, 617 Chroman-4-one, 2,2-diphenyl-synthesis, 3, 852 Chroman-4-one, 3-hydroxy-synthesis, 3, 856... 

Chroman-2-ylmethanol, (5)-6-hydroxy-2,5,7,8-tetramethyl-synthesis, 3, 779 Chromene, 3-acetyl-2-methoxy-synthesis, 3, 750 Chromene, 2-alkyl-synthesis, 3, 749 Chromene, 4-aryloxymethyl-synthesis, 3, 742-743 Chromene, bis(2,2-dimethyl-mass spectra, 3, 604 Chromene, 2,3-dichloro-synthesis, 3, 753 Chromene, 2,2-dimethyl-IR spectra, 3, 594 mass Spectra, 3, 604 molecular dimensions, 3, 621 synthesis, 3, 743, 749, 751 Chromene, 3-fluoro-2,2-dimethyl-synthesis, 3, 748 Chromene, 5-hydroxy-synthesis, 3, 745... 

The reaction of 1,3-dihydroxynaphthalene with 3,3-dimethylacrylic acid in the presence of phosphorus oxychloride and zinc chloride yields only 9-hydroxy-2,2-dimethyl-benzo[/]chroman-4-one (585). 2,7-Dihydroxynaphthalene similarly yields the angular ben-zochromanone (586) rather than the alternative linear product (79RRC59). 

Chroman 5,7-Dihydroxy-2,2-dimethyl-4-oxo- VI/4, 166 Cyclobuten 3,4-Dioxo-2-ethoxy-l-(2-hydroxy-l-cyclopentenyl)-E15/2, 1426 (NR2 OH) Cycloheptatrien 1,6-Dimethoxycar-bonyl- V/ld, 346... 

Chroman 2,2-Dimethyl-4-hydroxy-3-methoxy- VI/4, 219 Cycloheptatrien 7-tert.-Butylperoxy-carbonyl- E13/1, 810 (Cl - O-OR)... 

Apart from metabolism studies, which will be exclusively discussed in Chapter 8 the linking of HPLC to NMR spectroscopy provides a powerful tool for the identification of impurities in drugs. Using the stopped-flow technique, Roberts and Smith [8] were able to find minor components in a mixture of chromane compounds at a 3% level. Peng et. al. [9] Applied the LC-NMR to identify the degradation products of the protease inhibitor N-hydroxy-1,9-di-(4-ethoxybenzenesulfonyl)-5,5-dimethyl-( 1,3)cyclohexyl-diazine-2-carboxamide in a dosage formulation. 

Bidwillon B, B-10022 1 -[2,4-Dihydroxy-3-( 3-methy 1-2-buteny 1) phenyl]-3-(8-hydroxy-2,2-dimethy 1-2//-1 -benzopyran-6-yI)-2-propen-1 -one, D-30198 2-(2,4-Dihydroxyphenyl)-8,8-dimethyl-10-(3-methyl-2-butenyl)-8//-pyrano[2,3-rf) chroman-4-one, D-10234... 

Atroposelective cycloaddition reactions of A-2-(r-butylphenyl)- and A-2,5-(di-r-butylphenyl)-maleimide show good to excellent stereoselectivities and the high rotation barriers prevent cycloadducts from interconverting. The stereospeciflc hetero-Diels-Alder reaction of o-quinone methides (80) with o-quinones (79) in MeOH at room temperature produce the 4a,8-di(hydroxymethyl)chromane derivatives (81) and (82) in high yields (Scheme 29). The intramolecular inverse-electron-demand Diels-Alder reaction of o-quinone methides (84) derived from 2-(l-hydroxy-5-alkenyl)phenol derivatives (83) produces l,2,3,3a,4,9b-hexahydrocyclopenta[c][l]benzopyrans (85) under mild acidic conditions (Scheme 30). The Diels-Alder reactions between dimethyl-cyclohexadiene derivatives and di-(-)-menthyl acetylenedicarboxylate exhibit modest diastereoselectivity. ... 

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