Hydroxocobalamin vitamin

Hydroxocobalamin - Hydroxocobalamin (vitamin B- 2a) is more highly protein bound and is retained in the body longer than cyanocobalamin. However, it has no advantage over cyanocobalamin. 

Hydroxocobalamin (Vitamin B12) Naloxone (Narcan) Pralidoxime (2-PAM, Protopam)... 

Cyanocobalamin, the form of vitamin B12 isolated initially, contains cyanide attached to cobalt. It occurs only in minor amounts, if at all, in nature but is generated through the addition of cyanide during the isolation. Hydroxocobalamin (vitamin B12a) containing OH in place of CN"does occur in nature. However, the predominant forms of the vitamin are the coenzymes in which an alkyl group replaces the CN of cyanocobalamin. 

Hydroxocobalamin (vitamin another antidote, is a potential alternative to sodium nitrite treatment. It works by binding with cyanide to form nontoxic cyano-cobalamin (vitamin Bj ). Although effective and relatively safe in experimental models, the concentration available in the United States requires large infusion volumes and has a short shelf life due to light instability, and reports of anaphylactoid reactions have limited its use (8,13,21). Further studies using higher concentrations available in European formulations may eventually lead to its use as an outpatient alterative to sodium nitrite treatment in the United States (7,32). Other alternatives currently used or undergoing clinical trials in Europe include cobalt salts, limited by their toxicity, aldehydes, and aminophenol derivatives. These alternative treatments are not currently available in the United States (7). 

HYDROXOCOBALAMIN (VITAMIN Bj2a) (Alphamin, AlphaRedisol, Codroxomin,... 

Hydroxocobalamin (Vitamin (+NaHS0 ) Kit No methemoglobin Low toxicity High CN affinity Short shelf life (France) Orphan drug Post exposure Health dept, emergency dept. 

Greenbeig SS, Xie J et al (1995) Hydroxocobalamin (vitamin Bi2a) prevents and levtases endotoxin-induced hypotension and mortality in rodents role of nitric oxide. J Pharmacol Exp Ther 273 257-265... 

Other ions and neutral molecules can replace the cyano group in cyanocobalamin. Compounds such as hydroxocobalamin (vitamin Biaa), chloro-cobalamin, cyanatocobalamin, thiocyanatocobalamin, and nitrocobalamin, are known. The microbiological activity of these compounds by the L. lactis and L. leichmannii assays is from 30-100% of the activity of cyanocobalamin, depending upon the assay conditions employed. 

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