Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Hydroquinidine 1,4-phthalazinediyl diether DHQD 2PHAL

The best enantioselectivities (94-99% ee) were obtained with hydroquinidine 1,4-phthalazinediyl diether ((DHQD)2PHAL) as the ligand at 0-12 °C (Table 1.2, entries 1, 3, and 4). [Pg.10]

Backvall and coworkers have shown that other tertiary amines can assume the role of the N-methylmorpholine. They reported on the first example of an enantioselec-tive catalytic redox process where the chiral ligand has two different modes of operation (1) to provide stereocontrol in the addition of the substrate, and (2) to be responsible for the reoxidation of the metal through an oxidized form [17]. The results obtained with hydroquinidine 1,4-phthalazinediyl diether (DHQD)2PHAL both as an electron-transfer mediator and chiral ligand in the osmium-catalyzed dihydroxylation are comparable to those obtained employing NMM together with (DHQD)2PHAL. The proposed catalytic cycle for the reaction is depicted in Scheme 1.4. [Pg.4]

Of the quinuclidine-ligated transition metal catalyzed processes, the osmium-catalyzed asymmetric dihydroxylation of alkenes, developed by Sharpless, has had the greatest impact on synthetic chemistry (67). In a recent synthesis, 1,3-dienoates were dihydroxylated with high enantioselectivities in the presence of (DHQD)2PHAL (hydroquinidine 1,4-phthalazinediyl diether) (Fig. 19) (183). [Pg.698]


See other pages where Hydroquinidine 1,4-phthalazinediyl diether DHQD 2PHAL is mentioned: [Pg.199]    [Pg.365]    [Pg.4]    [Pg.258]    [Pg.8]    [Pg.1335]    [Pg.199]    [Pg.365]    [Pg.4]    [Pg.258]    [Pg.8]    [Pg.1335]    [Pg.473]    [Pg.488]   
See also in sourсe #XX -- [ Pg.4 ]




SEARCH



1.3- diethers

Diether

Hydroquinidine

Hydroquinidine 1,4-phthalazinediyl diether

© 2024 chempedia.info