Hydrophobically - modified poly N - isopropylacrylamides

It was also observed that nonionic amphiphilic ABA polymers (e.g., PEO-PPO-PEO) [200,205], polycations (e.g., quaternized poly(4-vinylpyridine) [214] and hydrophobically modified poly(N-isopropylacrylamide) [204] are able to accelerate translocation from the inside leaflet to the outside leaflet ( flip-flop ) within... 

J. E. Chimg, M. Yokoyama, T. Aoyagi, Y. Sakurai and T. Okano Effect of molecular architecture of hydrophobically modified poly(N-isopropylacrylamide) on the formation of thermorespon-sive core-shell micellar drug carriers./. Control. Release, 53,119-130 (1998). 

Ringsdorf H, Venzmer J, Winnik EM. Interaction of hydrophobically modified poly(N-isopropylacrylamide) with model membranes—Or playing a molecular accordion. An w Chem... 

Affinity chromatography of streptavidin was performed on a PET chip. The microchannel was first filled with the dual-modified latex beads (as shown in Figure 6.3). The biotinylated beads were surface-modified with a temperature-sensitive polymer, poly(N-isopropylacrylamide (PNIPAAm, 11 kDa). When the temperature was raised above the lower critical solution temperature (LCST) of PNIPAAm, the beads aggregated and adhered to the channel wall, because of a hydrophilic-to-hydrophobic phase transition. Then streptavidin from a sample solution was captured by these adhered biotinylated beads. Thereafter, when the temperature was reduced below the LCST, the beads dissociated and eluted from the channel wall together with the captured streptavidin [203],... 

Yakushiji T, Sakai K, Kikuchi A et al. Effects of cross-linked structure on temperature-responsive hydrophobic interaction of poly(N-isopropylacrylamide) hydrogel-modified surfaces with steroids. Anal Chem 1999 71 1125-1130. 

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