Hydrophilic pharmaceutical cyclodextrins

Part II starts with the possibilities of ACE for characterizing the relevant physicochemical properties of drugs such as lipophilicity/hydrophilicity as well as thermodynamic parameters such as enthalpy of solubilization. This part also characterizes interactions between pharmaceutical excipients such as amphiphilic substances (below CMC) and cyclodextrins, which are of interest for influencing the bioavailability of drugs from pharmaceutical formulations. The same holds for interactions of drugs with pharmaceutical vehicle systems such as micelles, microemulsions, and liposomes. 

Synthetic methods in dendrimer chemistry have developed in recent year to such an extent that one can obtain dendrimers with hydrophilic surface and hydrophobic inside. In such a way dendrimers can exhibit solubilizing effect analogous to that shown by micelles. Similarly to cyclodextrins 278 in the pharmaceutical industry discussed in Sect. 6.3.3, dendrimers can be used as drug... 

---