Hydromagnesiation of Conjugated Dienes

The observed regioselection of hydromagnesia-lion is identical with that of the hydrotitaiunion of the same substrates with a stoichiometric amount 

Nickel-cataly/.ed hydromagncsialion of conjugated diene s with Grignard reagents seems less fruitful from Ihe s nihenc point of view. Attempted reactions of butadiene and isoptene resulted in a formal hydromagiiesiation of the corresponding 

Ordinary hydromagncsialion may be effected by the use of a nickel-pyridine complex like Ni(py)4Ch. even though it affords a mixture of rcgioisomcrie allylmagnesium reagents as determined by carboxylalion. giving two kinds of carboxylic acids (eq. 3.37) (5(). An alkoxybntadicne underwent the alkylation as well 

---

Table 3.4. Hydromagnesiation of conjugated dienes with Grignard reagents...

Ni-catalyzed hydromagnesiation 78 of conjugated dienes 81 see also Hydromagnesiation... 

Since then, hydromagnesiation of other unsaturated hydrocarbons such as conjugated dienes and acetylenes has been investigated intensively.5 6 Hydromagnesiation of 2-alkyl substituted 1,3-butadienes has been shown to proceed... 

---