Hydrolysis neighbouring-group-assisted

C for periods of up to 6h. In other cases, amides have resisted hydrolysis even during reflux in 48% hydrobromic acid/acetic acid (2). Helmchen el al. [63] reported the directed separation and recovery of acids by neighbouring group assisted hydrolysis. Using amino alcohols as chiral reagents to form amides with the hydroxyl function y or to the carbonyl gave excellent separation factors, and also allowed the hydrolysis to be carried out under somewhat milder conditions, e.g. in 3 M sulphuric acid. 

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