Hydrogenation of Substituted Alkenes

Ferrocene-based complexes have some potential for the enantioselective reduction of ketones, but compared to other ligand classes this is relatively limited [3]. Rh complexes of bppfa, bophoz and josiphos are among the most selective catalysts for the hydrogenation of a-functionalized ketones (Table 25.9 Fig. 25.18, 30-32). Ru complexes of walphos and ferrotane are quite effective for 

9 (a) M. Lotz, T. Ireland, J. Almena Perea, P. Knochel, Tetrahedron Asymmetry 1999, 10, 1839 (b) J. Almena Perea, A. Borner, P. Knochel, Tetrahedron Lett. 1998, 39, 8073 (c) J. Almena Perea, M. Lotz, 

Rivas-Nass, O. Briel, H.U. Blaser, Tetrahedron Asymmetry 2004, 15, 2299. 

10 For more information see www.solvias.-com/ligands. M. Thommen, H.U. Blaser, PharmaChem, July/August, 2002, 33. 

Gosberg, R. Goddard, S.-H. Kyung, Chem. Commun. 1998, 

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