Hydrogen cyanide derivatives, synthesis

Homolytic substitution of heteroaromatic compounds, 16, 123 Hydantoins, chemistry of, 38, 177 Hydrogen cyanide derivatives, synthesis of heterocycles from, 41, 1 Hydrogen exchange base-catalyzed, 16, 1 one-step (labeling) methods, 15, 137 Hydrogenated porphyrin derivatives hydroporphyrins, 43, 73 Hydroxamic acids, cyclic, 10, 199 1 -Hydroxyindoles, 1 -hydroxytryptophans, and 1-hydroxytryptamines,... 

Synthesis of Heterocycles from Hydrogen Cyanide Derivatives D. S. Donald and O. W. Webster... 

Hydrogen cyanide derivatives in synthesis of heterocycles 87AHC(41)1. 

Synthesis of imidazoles from hydrogen cyanide derivatives 87-AHC(41)1. 

The preparation of a formyl-substituted aromatic derivative 3 from an aromatic substrate 1 by reaction with hydrogen cyanide and gaseous hydrogen chloride in the presence of a catalyst is called the Gattermann synthesis This reaction can be viewed as a special variant of the Friedel-Crafts acylation reaction. 

Many of the synthetic routes derived for pregabalin (2) before 2003 have relied on classical chiral resolution of either an intermediate or the final racemic 3-isobutyl GABA (43). In 2003, Jacobsen and co-workers published their work on a novel enantio-selective synthesis of pregabalin (2) (Sammis and Jacobsen, 2003). The Harvard group was able to promote conjugate addition of hydrogen cyanide into the unsaturated imide... 

The control chemical interest of the mercaptans essentially is in the derivatives that incorporate chlorine or bromine. Methyl mercaptan rivals hydrogen cyanide as a powerful and useful fumiganl. This compound is also an importani intermediate in the synthesis of Caplan and Folpet fungicides. 

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