Hydrogen bonding-induced circular dichroism

Hydrogen Bonding-Induced Circular Dichroism (HBICD)... 

Hie generality of the induced circular dichroism with the three nitrosamines and four alcohols (Table 1) indicates that this technique will provide a method for studying interactions of nitrosamines with biological systons such as enzymes. Hi is method furnishes a highly sensitive procedure for detecting an interaction of nitrosamines with any chiral hydrogen bonding donor. 

Dyes can also be incorporated into hydrogen-bonded superstructures using the complementarity of the hydrogen bond donors and acceptors. The addition of a perylene bisimide dye to chiral dialkyl melamine derivatives leads to aggregates (Fig. 26) which show induced circular dichroism in the dye part of the assembly in methylcyclohexane as well as the formation of mesoscopic fibres when the solvent is evaporated [227]. The melamine compounds... 

Mizutani T, Ema T, Yoshida T, Kuroda Y, Ogoshi H. Recognition of a-amino acid esters by zinc porphyrin derivatives via coordination and hydrogen bonding interactions. Evidence for two-point fixation from thermodynamic and induced circular dichroism spectroscopic studies. Inorg Chem 1993 32 2072-7. 

It has also been reported from circular dichroism (CD) studies [36] that polysaccharide-based CSPs can induce chirality in enantiomeric guests such as (4Z,15Z)-bilirubin-Ixoc (BR) (Fig. 5). Although not optically active, BR has two enantiomeric helical conformations maintained by six intramolecular hydrogen bonds between two carboxylic acid moieties and two pyrromethenone — NH— protons. These (R)- and (5)-helical conformers are in dynamic equilibrium in an achiral solution [37], but some optically active compounds can enantioselectively bind to BR to induce CD spectra in solution [38-40]. A significant induced CD... 

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