Hydrogen bonding in nucleic acids

Explain, with the aid of structures, the role of hydrogen bonding in nucleic acid structures. 

Buskov VI, Bushnev VN, Poltev VI (1980) Nuclear magnetic resonance study of C-H—O hydrogen bonds in nucleic acid base analogs. Mol Biol (USSR) 14 245-250 (in English)... 

Turner DH, Sugimoto N, Kierzek R, Dreiker SD. Free energy increments for hydrogen bonds in nucleic acid base pairs. J. Am. 

In all these events, the hydrogen-bonded Watson-Crick base pair is operative and is responsible for DNA reduplication, transcription, and translation. Since mispairing can occur, all these processes are checked for fidelity by several enzymes which can correct for errors [6521. At this and all other levels of DNA reduplication and protein biosynthesis, intermolecular hydrogen bonds between nucleic acids and between nucleic acids and proteins are responsible for recognition, interaction, and, finally, for information transfer. 

Hardman SJO, Thompson KC (2006) Influence of base stacking and hydrogen bonding on the fluorescence of 2-aminopurine and pyrrolocytosine in nucleic acids. Biochem 45 9145-9155... 

Pentynoic acid, 5 34t People. See also Personnel investment in, 21 624 organizational ties to, 21 627-628 People s Republic of China. See also China demand for oil in, 23 530 oil recovery program in, 23 534 Pepper, pipeline levels in, 23 159 Peptide antibiotics, 18 252-253. See also Antimicrobial peptides Peptide backbone hydrogen bonds, in proteins, 20 826 Peptide mapping, 3 840-841 Peptide nucleic acids, 17 631-634... 

Recently, electron-mediated, scalar couplings which are active between magnetic nuclei on both sides of the hydrogen bridge have been discovered in nucleic acids [28-41], proteins [42-54] and their complexes (Tabs. 9.1-9.3) [54—56]. These couplings are closely related to similar inter- and intramolecular couplings across H-bonds in smaller chemical compounds [57-60]. It is well established [31, 58, 61-74] that such trans H-bond scalar couplings follow the same electron-mediated polarization mechanism as any covalent... 

Tab. 9.1 Observed trans hydrogen bond couplings in nucleic acids...

The number of possible forms is reduced somewhat by the fact that one of the nitrogens is bonded to the sugar in the nucleic acid it no longer carries a hydrogen to participate in tautomerism. The tautomeric forms indicated are found to predominate in nucleic acids. The oxygen substituents exist almost entirely as carbonyl groups, whereas... 

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