Hydrogen bonding cooperative self-assembly

J.H.K.K. Hirschuberg, L. Brunsveld, A. Ramzi, J.A.J.M. Vekemans, R.P. Sijbesma, E.W. Meijer, Helical Self-Assembled Polymers from Cooperative Stacking of Hydrogen-Bonded Pairs , Nature, 407, 167 (2000)... 

The easiest way to construct active sites of artificial enzymes is self-assembly of the active sites as illustrated by the cartoon of 60. If the catalytic groups take highly productive positions in the self-assembled active site, cooperation among them can result in effective catalysis. It is difficult to induce the self-assembly in aqueous solutions by using hydrogen bonding or electrostatic interactions as intermolecular... 

Bolaform sugar amphiphiles 68 exhibit columnar mesophases [154]. The aggregated structures of 68 in aqueous media depend on the stereochemical factors of the spacers. Layered structures are formed in crystalline states by self-assembly of glucopyranose-based bolaamphiphiles due to the cooperation of the hydrogen-bonding interactions of hydroxyl groups and amide linkages [155]. 

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