Hydrogen-bonded assemblies, noncovalent synthesis

For dynamic processes involving hydrogen-bonded entities, see (a) Calama MC et al (1998) Libraries of non-covalent hydrogen-bonded assemblies combinatorial synthesis of supramolecular systems. Chem Commun 1021-1022. (b) Timmerman P et al. (1997) Noncovalent assembly of functional groups on Calix[4]arene molecular boxes. Chem Eur J 3 1823-1832. (c) Cai MM et al. (2002) Cation-directed self-assembly of lipophilic nucleosides the cation s central role in the structure and dynamics of a hydrogen-honded assembly. Tetrahedron 58 661-671... 

The formation of synthetic hydrogen-bonded structures is typically achieved under thermodynamic control. Therefore, product formation is usually quantitative because erroneous structures can dissociate and recombine to give the correct assembly. However, it is expected that a large increase in the number of hydrogen bonds will lead to a kinetic control in the self-assembly process limiting the use of noncovalent synthesis of nanostructures. 

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