Hydroformylation-Wittig Reactions and Related Olefinations

Risi and Burke [29, 30] synthesized (+)-patulolide C, which is a macrocyhc compound isolated from a Penicillium urticae mutant via an asymmetric sequential hydroformylation-(intramolecular Wittig olefination) reaction applying 

2) For the total synthesis of other macrocyles, such as (-)-pyrenophorol and (+)-decaestrictine via similar asymmetric hydroformylation-Wittig olefination cascade reactions, see Ref. (30). 

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