Hydroformylation continuous asymmetric

Scheme 24 Continuous asymmetric hydroformylation using gases as reactants and fluids...

Fine chemical applications of rhodium-catalyzed hydroformylation have steadily increased over the past 20 years. Use of this chemistry in the fragrance industry appears to be relatively common. Pharmaceutical applications have started to increase as the technology becomes more familiar to process chemists. The commercial availability of ligands for both linear-selective hydroformylation and asymmetric hydroformylation has removed a barrier for screening catalysts by synthetic chemists. As additional large-scale examples of rhodium-catalyzed hydroformylation continue to be published, we expect this technology to be applied even more widely to fine chemical synthesis. 

Figure 3.3. Asymmetric hydroformylation of non-volatile substrates using a stepwise injection into continuous flow reactor with scCC>2 as mobile phase...

The asymmetric hydroformylation of aryl ethenes such as substituted styrene and substituted -naphthyl ethene will lead to the intermediates for important pharmaceuticals. Much concerted effort has been applied to achieve high enantioselectivity as well as high regioselectivity toward the branched aldehydes. The research work in this area is of great industrial interest, and it continues to be a dynamic field of study. 

---