Hydrazones, Osazones, and Derived Heterocycles

Acetylation of the isonicotinoylhydrazone of sodium D-glucuronate (which exists in the -pyranose form) gave the 6,1-lactam derivative (31)) the conformation of which was examined in detail. A variety of N-6-D-glucopyranosylated heterocycles have been synthesized by condensation of 2,3,, 6-tetra-O-benzyl-D-glucose hydrazone (which exists as a mixture of ring and chain isomers) with acetyl-acetone [leading to the synthesis of the 3,5-dimethylpyrazole derivative (32)], (ethoxymethylene)malondinitrile, (ethoxymethylene) 

A reinvestlgatlon of the dehydration of D-galacto-heptulose phenylosazone showed the product to be a mixture of the 3,7-anhydrides (33) with a pyranosyl ring, and not the furanosyl 3 6-anhydro-counterparts as previously claimed (Vol.l4, p.88) further data on such dehydration reactions is detailed in Section 6. Further details on the dehydratlve cyclization of the phenylosazones of L-lyxo- and L-xylo-hexulose and 7-deoxy-L-manno-heptulose have been reported (Vol.liJ, p.88 V0I.15, p.ll2). °  

The action of hydrogen bromide in acetic acid on dehydro-L- 

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Nitriles, Isonitriles, Oximes, and Hydroxylamines Hydrazones, Osazones, and Derived Heterocycles Other Heterocyclic Derivatives... 

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