Hydration theory further applications

A hybrid approach of the extended scaled particle theory (SPT) and the Poisson-Boltzmann (PB) equation for the solvation free energy of non-polar and polar solutes has been proposed by us. This new method is applied for the hydration free energy of the protein, avian pancreatic polypeptide (36 residues). The contributions form the cavity formation and the attractive interaction between the solute and the solvent to the solvation free energy compensate each other. The electrostatic conffibution is much larger than other terms in this hyelration free energy, because hydrophilic residues are ionized in water. This work is the first step toward further applications of our new method to free energy difference calculation appeared in the stability analysis of protein. 

In this book special reference is made to polymer associations of various types -binding of small molecules by polymers, polymer hydration, block-copolymerization, thermoreversible gelation, and their flow properties. These topics do not, by any means, exhaust the possibilities of the method. They serve, however, to illustrate its power. The author hopes that others will be stimulated by what has already been done to attempt further applications of the theory of associating polymer solutions. 

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