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Hydantoin and derivatives

C-nmr data have been recorded and assigned for a great number of hydantoin derivatives (24). As in the case of H-nmr, useful correlations between chemical shifts and electronic parameters have been found. For example, Hammett constants of substituents in the aromatic portion of the molecule correlate weU to chemical shifts of C-5 and C-a in 5-arylmethylenehydantoins (23). Comparison between C-nmr spectra of hydantoins and those of their conjugate bases has been used for the calculation of their piC values (12,25). N-nmr spectra of hydantoins and their thio analogues have been studied (26). The N -nmr chemical shifts show a linear correlation with the frequencies of the N—H stretching vibrations in the infrared spectra. [Pg.250]

Similar alkylations may be effected on oxygen. l-(2-Chloroethyl)imidazolidin-2-one (312) when treated with potassium hydroxide or sodium hydride underwent ring closure to the tetrahydroimidazo[2,l-6]oxazole (313) (57JA5276). This approach can be used for the preparation of bicyclic hydantoins and the corresponding dihydro derivatives of (313) using the mesylate of (312) and NaH (77JHC5U, 79JMC1030). [Pg.139]

Lopez-Rodriguez, M.L., Rosado, M.L., Benhamu, B., Morcillo, M.J., Fernandez, E. and Schaper, K.-J. (1997) Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of new hydantoin-phenylpiperazine derivatives with affinity for 5-HTIA and oq receptors. A comparison of CoMFA models. Journal of Medicinal Chemistry, 40, 1648-1656. [Pg.474]

Sulfahydantoins 87 and 88 are analogues of hydantoins and provide heterocyclic scaffolds with a great potential for the construction of bioactive compounds. A total of 28 derivatives, with crude purity generally higher than 85%, were prepared by parallel synthesis using an oxime resin as a solid support (Scheme 46) . The results constitute the first report of successful Mitsunobu reactions and reductive alkylations on the oxime resin. [Pg.187]

ANTIBACTERIAL AGENTSSYNTHETIC - NITROFURANS] (Vol 2) ofhydantoins [HYDANTOIN AND ITS DERIVATIVES] (Vol 13)... [Pg.62]

Antitumor activity - [ANTIBIOTICS - ANSAMACROLIDES] (Vol2) - [ANTIBIOTICS - ANSAMACROLIDES] (Vol2) -of enzymes [ENZYME APPLICATIONS - THERAPEUTIC] (Vol9) -ofhydantoins [HYDANTOIN AND ITS DERIVATIVES] (Vol 13)... [Pg.65]

See other pages where Hydantoin and derivatives is mentioned: [Pg.258]    [Pg.534]    [Pg.188]    [Pg.127]    [Pg.188]    [Pg.631]    [Pg.258]    [Pg.534]    [Pg.188]    [Pg.127]    [Pg.188]    [Pg.631]    [Pg.59]    [Pg.65]    [Pg.368]    [Pg.471]    [Pg.485]    [Pg.788]    [Pg.912]    [Pg.249]    [Pg.249]    [Pg.250]    [Pg.251]    [Pg.252]    [Pg.253]    [Pg.254]    [Pg.255]    [Pg.256]    [Pg.257]    [Pg.258]    [Pg.259]    [Pg.260]    [Pg.192]    [Pg.29]    [Pg.41]    [Pg.59]    [Pg.60]    [Pg.61]    [Pg.81]    [Pg.98]    [Pg.102]    [Pg.112]    [Pg.112]    [Pg.131]    [Pg.131]    [Pg.132]    [Pg.135]    [Pg.240]   
See also in sourсe #XX -- [ Pg.793 ]



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HYDANTOIN AND ITS DERIVATIVES

Hydantoin

Hydantoin and derivs

Hydantoin and derivs

Hydantoin derivatives

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