Hycanthone methanesulfonate

Some or all events leading to sex-chromosome loss or nondisjunction are either not inducible in or not recoverable from some of the germ cell stage.378 However, very few chemicals have been tested, and none in all germ cell stages. Sex-chromosome loss has been shown to be induced by triethylenemelamine in spermatids and spermatozoa, 55 by isopropyl methanesulfonate in primary oocytes within 6 wk of being ovulated,138 and by hycanthone methanesulfonate in primary oocytes within 1 wk of being ovulated.38 ... 

All pesticides were at least 97% pure preparations and were obtained from Chem Service, West Chester, Pennsylvania, except for Strobane, which was kindly donated by Tcn-neco Co, Piscataway, New Jersey, and A (2-hydroxyethyl)hydrazine, which was obtained from Pfaltz and Bauer, Inc., Stamford, Connecticut. Cyclophosphamide was the injectable form obtained from Mead Johnson Laboratories, Evansville, Indiana benzo[a]pyrene and 9-aminoacridine were obtained from Sigma Chemical Co., St. Louis, Missouri methyl methanesulfonate was obtained from Aldrich Chemical Co., Milwaukee, Wisconsin hycanthone methanesulfonate was a gift from Dr. Ernest Bueding. All compounds were dissolved in 100% dimethyl sulfoxide, except N-(2-hydroxyethyl)hydrazine, which was dissolved in distilled water. 

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