Hybrids including time-of-flight with orthogonal acceleration

3 Hybrids Including Time-of-Flight with Orthogonal Acceleration 

As already mentioned, when ions fragment during their flight in a field-free region, with or without collision activation, the precursor and fragments have the same velocity and reach the detector simultaneously. If, however, they are accelerated perpendicularly to their trajectories and so pushed in the TOF mass analyser, ions with different masses will arrive at different times and will be detected separately according to their respective m/z [80]. However, owing to their initial velocities, they will reach the array detector at different places. 

In principle, it is also possible to use the scanning capability of Ql, using the TOF part only as a total ion current detector. However, this scan mode is not used, as all the above-mentioned advantages of using the TOF analyser are lost. 

A partial treatment of this problem can be found in March, R.E. and Hughes, R.J. (1989) Quadrupole Storage Mass Spectrometry, John Wiley Sons, Inc., New York. For a detailed treatment, see also the work of the mathematician R. Campbell, Theorie Generate de 1 Equation de Mathieu, Masson, Paris, 1955. 

and Hughes, R.J. (1989) Quadrupole Storage Mass Spectrometry, John Wiley Sons, Inc., New York. 

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