Hyaluronic acid knee pain

Chondroitin Sulfate and Glucosamine in OA therapy have efficacy comparable to placebo as showed by a National Institute of Health study. Intraarticular hyaluronic acid for pain relief is inferior compared to intraarticular corticosteroids. Temporary crepitus reduction or eradication may last several years in radiological stages I and II Knee OA with intraarticular hyaluronic acid. 

Four intraarticular hyaluronic acid preparations are available for treating pain associated with OA of the knee sodium hyaluronate (Hyalgan 20 mg/2 ml Supartz 25 mg/2.5 mL), hylan polymers (Synvisc 16 mg/2 mL), and hyaluronan (Orthovisc 30 mg/2 mL). Hyalgan and Supartz are administered once weekly for five injections, whereas Synvisc and Orthovisc are administered once weekly for three injections. 

Hyaluronic acid formulations Orthovisc (Anika/Ortho Biotech) Pain with osteoporosis of knee... 

Hyaluronic acid improves elasticity and viscosity of synovial fluid. It is indicated in the treatment of pain of osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics (e.g., acetaminophen) and mid to deep dermal implantation for correction of moderate to severe facial wrinkles and folds, such as nasolabial folds (Restylane). 

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