Hyaluronic Acid Carriers with Calcium Phosphate Particles

3 Hyaluronic Acid Carriers with Calcium Phosphate Particles 

HA has been used, both in soluble and crosslinked forms, as a carrier for calcium phosphate particles to stimulate bone regeneration. In a subcutaneous implantation model, an injectable paste-like material, consisting of beta-tricalcium phosphate (P-TCP), methylcellulose, and HA, increased the half-life of the P-TCP particles and ultimately vascularisation of the implantation bed [99]. In a unilateral tibial defect model in rabbits, the same formulation promoted a significant increase in new bone volume fraction after one week however, by 4 weeks, there was no difference in bone formation compared to controls [100]. Similarly, medical grade HA of three different MW (900,000 - Artz 1,900,000 - Suvenyl and 6,000,000 - Synvisc) were evaluated as carriers for octacalcium phosphate granules in a mouse subperiosteal calvarial model [101]. The formulations with 

Artz and Synvisc enhanced bone formation compared to the particles alone, by stimulating osteoclastic resorption of the particles [101]. 

---