Humans, pharmacokinetic studies

Unlike the simple example of the solution described above, a human body is a complex mixture of components (tissues, proteins, membranes, etc.). Yet, in human pharmacokinetic studies, with rare exceptions only the plasma... 

Validation of the Model. The Corley model was validated using chloroform data sets from oral (Brown et al. 1974a) and intraperitoneal (Ilett et al. 1973) routes of administration and from human pharmacokinetic studies (Fry et al. 1972). Metabolic rate constants obtained from the gas-uptake experiments were validated by modeling the disposition of radiolabeled chloroform in mice and rats following inhalation of chloroform at much lower doses. For the oral data set, the model accurately predicted the total amounts of chloroform metabolized for both rats and mice. 

Because there is no human pharmacokinetic study evaluating this potential interaction or metabolic study data showing an effect of ginseng... 

For human pharmacokinetic studies, infonnation on study design and methods used along with the pharmacokinetic data... 

Uno, T. and Yasui-Furukori, N., Effect of grapefruit juice in relation to human pharmacokinetic study, Curr. Clin. Pharmacol., 1(2), 157, 2006. 

Band, C.J. Band, P.R. Deschamps, M. Besner, J.-G. Goldman, A.J. Human pharmacokinetic study of immediate-release (codeine phosphate) and sustained-release (codeine contin) codeine. J.Clin. Pharmacol., 1994, 34, 938-943 [electrochemical detection SPE plasma ethylmorphine (IS)] Papadoyannis, I. Zotou, A. Samanidou, V. Theodoridis, G. Zougrou, F. Comparative study of different solid-phase extraction cartric es in the simultaneous RP-HPLC analysis of morphine and codeine in biological fluids. J.Liq.Chromatogn, 1993,16, 3017—3040 [simultaneous caffeine, morphine, quinine, strychnine SPE urine plasma LOD 10-20 ng/mL]... 

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