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Humanization technologies, antibody

A.M. Campbell, Monoclonal Antibody and Immunosensor Technology the Production and Application of Rodent and Human Monoclonal Antibodies, Elsevier, Amsterdam (1991). [Pg.675]

Reiter, M., Buchacher, A., Bltlml, G., Zach, N., Steinfellner, W., Schmatz, C., Gaida, T., Assadian, A., and Katinger, H., Production of the HIV-1 Neutralising Human Monoclonal Antibody 2F5 Stirred Tank Versus Fluidized Bed Culture, Animal Cell Technology, (R. E. Spier, J. B. Griffith, and W. Berthold, eds.), p. 333, Butterworth-Heinemann, Oxford (1994)... [Pg.676]

Humira (EU USA also sold as Trudexa in EU) (adalimumab r (anti-TNF) human monoclonal antibody created using phage display technology Cambridge Antibody Technologies Abbott (USA) Abbott (EU) Rheumatoid arthritis... [Pg.381]

Figure 13.9 Production of chimaeric (a) and humanized (b) antibodies (via recombinant DNA technology). Chimaeric antibodies consist of murine monoclonal VH and VL domains grafted onto the Fc region of a human antibody. Humanized antibody consists of murine CDR regions grafted into a human antibody... Figure 13.9 Production of chimaeric (a) and humanized (b) antibodies (via recombinant DNA technology). Chimaeric antibodies consist of murine monoclonal VH and VL domains grafted onto the Fc region of a human antibody. Humanized antibody consists of murine CDR regions grafted into a human antibody...
Explain why the humanization of antibodies is important and, through the use of examples, demonstrate the progress made to the modification of antibodies as technology advances. [Pg.132]

Efalizumab is a humanized IgGlK antibody produced by recombinant DNA technology. It exhibits immunosuppressive function. It binds to CDlla, which is the a-subunit of leukocyte function antigen (LFA)-l. Efalizumab decreases the cell... [Pg.113]

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