Human serum albumin-drug binding constant

The frontal analysis technique has been used for the determination of enantioselective binding constants of chiral drugs such as warfarin, verapamil, nilvadipine, and semotidil with proteins such as bovine serum albumin (BSA), human serum albumin (HSA), and plasma lipoproteins (45-51). 

J Sowell, JC Mason, L Strekowski, G Patonay. Binding constant determination of drugs toward subdomain IIIA of human serum albumin by near-infrared dye-displacement capillary electrophoresis. Electrophoresis 22 2512-2517, 2001. 

Very recently, we also fitted a model for another physiological partition coefficient, the adsorption to human serum albumin. Since the albumin protein has the potential to bind a large portion of drugs in the blood serum, a drug should not bind strongly to albumin in order to be available for the real target. We used a data set of 92 human albumin binding constants published in a white paper by Kier et al. [140] and achieved the model... 

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