Human Rhinovirus coat protein

Human rhinovirus coat protein Common cold Attachment to host cell receptor, viral entry, and uncoating Binding in hydrophobic pocket (capsid stabilization)... 

Most of the studies based on virtual screeiung use a hierarchical approach combiiung several conceptually different techniques. The most common combination used is a 3D pharmacophore modeling followed by a docking study, hi Figure 15.58 is reported an illustrative example of this combined use a set of 10 known inhibitors of Human Rhinovirus Coat protein was used to design a 3D pharmacophore... 

Steindl, T. M., Crump, C. E., Hayden, E. G., Langer, T. Pharmacophore modeling, docking, and principal component analysis based clustering combined computer-assisted approaches to identify new inhibitors of the human rhinovirus coat protein. 7. Med. Chem. 2005, 4S(20), 6250-6260. 

Related picoma viruses such as human rhinoviruses (Fig. 7-15),69/78/79 foot-and-mouth disease virus, parvovirus,80 and Mengo virus81 have similar architectures. The small (diameter 25 nm) single-stranded DNA bacteriophages such as ( )X174 also have three different coat proteins, one of which forms small hollow spikes at the vertices of the icosahedral shell (Fig. 5-41A).82... 

Figure 11-8. The capsid of the human rhinovirus is enc sulated between two ico-dodecahedra, one external and one internal scaled with a factor 1/r, with r the golden ratio. All vertices belong to the same icosahedral lattice. Only the vertices and the monomeric chains of the four coat proteins VPl, VP2, VP3 and VP4 in die various equatorial regions are plotted in projected views along the fivefold, the twofold and die direefold axes, respectively (adapted from [27], courtesy lUCr)...

Figure 11-9. The cluster with 222 symmetry of four VPl coat proteins taken from the human rhinovirus is enclosed in molecular forms with vertices at points of an integral tetragonal lattice with lattice parameters a = ra( /9, b = c = tuq/S, in which Uq is the icosahedral lattice parameter and t the golden ratio (adapted from [27], courtesy lUCr)...

Drug molecule Human rhinovirus. 16 coat protein... 

---