Human Proteome Organization

Enriched subcellular compartments can be analyzed by MS/MS to determine their constituent proteins. One advantage of analysis of different cellular fractions is pre-analytical simplification that offers rewarding yields in dealing with the proteins identified in large-scale MS experiments. One of the major initiatives of the Human Proteome Organization (HUPO) is the comprehensive characterization of the complete subproteome of each cell type. 

Riding on the success of the Human Genome Project in cataloging the 30,000 to 40,000 genes of the human genome, the Human Proteome Organization (HUPO http / /www.hupo.org) has set out to determine the entire set of expressed proteins comprising the human proteome(s). As Tyers and Mann... 

However, it is clear that the ease of collecting proteome data currently exceeds the capacity to analyse it. Therefore, international standards are being sought for proteomic experiments, such as the proteomics standards initiative (PSI, http //psidev.source forge.net/), and the proteomics experiment data repository (PEDRo, http //pedro.man.ac.uk). The aim is to provide proteomic researchers with the opportunity to query and reproduce protocols, analyse raw or metadata from other laboratories, and to link the proteome with the respective transcriptome and the metabolome. The Human Proteome Organization (HUPO) is establishing a defined infrastructure for human data submission, and annotation for the numerous proteomic data platforms. This will also be required to effectively develop parasitic flatworm proteomics. 

Merrick BA. The human proteome organization (HUPO) and environmental health. EHP Toxicogenomics 2003 lll(lt) l-5. 

Human Proteome Organization. E-mail hupo proteomix.org. URL http //hupo.org/. 

The Human Proteome Organization has initiated an effort to establish standards for the interchange of information between the various interaction databases. The... 

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