Human Metabolism and Requirement

Although accounts of scurvy symptoms are described as far back as the ancient Egyptians, the recognition and search for a scurvy cure began with the severe 

Robert A. Jacob U.S. Department of Agriculture, Agricultural Research Service, The Presidio at San Francisco, San Francisco, California 94129. 

Subcellular Biochemistry, Volume 25 Ascorbic Acid Biochemistry and Biomedical Cell Biology, edited by J. Robin Harris. Plenum Press, New York, 1996. 

FIGURE 1. Reversible two-electron oxidation/reduction of ascorbic acid to dehydroascorbic acid and back via reduced glutathione (GSH). 

FIGURE 2. Concentrations of ascorbic acid (mean sem) in plasma and mononuclear and buccal cells of eight healthy men receiving various ascorbate intakes from 5 to 250 mg/day (shown at bottom). 

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