Human light chain loci

Combriato, G. Klobeck, H.-G. (1991). and J -C gene segments of the human immunoglobulin X light chain locus are separated by 14 kb and rearrange by a deletion mechanism. Eur. J. Immunol. 21, 1513-1522. 

Udey, J.A. Blomberg, B. (1987). Human X light chain locus organization and DNA sequences of three genomic J regions. Immunogenetics 25,63-70. 

Figure 33.14. The k Light-Chain Locus. This part of human chromosome 2 includes an array of 40 segments that encode the variable (V) region (approximately residues 1 - 97) of the light chain, an array of 5 segments that encode the joining (J) region (residues 98-110), and a single region that encodes the constant (C) region.

Light chains controlled by the c locus appear, from a comparison with human and mouse L chains, to be of the X type (71-73). The evidence includes the presence of a blocked N-terminal group (pyrrolidone-carboxylic acid), the C-terminal dipeptide, -Cys-Ser, characteristic of k chains, and the sequence of eight amino acids at the C-terminus (Table 9.2). 

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