K locus organization

A detailed cloning and sequence study of the VK21 gene family of BALB/c mice also showed that highly homologous VK genes are physically clustered [46], It should be stressed, however, that family member interspersion of some degree has not been ruled out by any experiments to date. 

Lotscher et al. [55] have recently shown by somatic cell genetics that human VK genes are dispersed among several chromosomes. These investigators estimate that about 10% of human VK gene sequences may be located on chromosomes other than chromosome 2, to which the functional k locus maps. 

The two A clusters have not been psysically linked so that the distance between the Ja2-Ca2-Ja4-Ca4 cluster and the JA3-CA3-JA1-CA, cluster is unknown, as is the relative orientation of the clusters. Furthermore, the location of the VA genes is unknown except that the VA and CA genes are tightly linked on chromosome 16 [89]. 

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See also in sourсe #XX -- [ ]

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