Human holo-transferrin

Zhao, Y.Y., Mandal, R. and Li, F.X., Intact human holo-transferrin interaction with oxaliplatin. Rapid Commun. Mass Spectrom., 19(14), 1956-1962 (2005). 

The Fe +/ + reduction potentials for holo-transferrin have been difficult to determine because of their low values and the need to take account of the dissociation of Fe(II) from diferrous-transferrin. This has been estimated from the association constant for Fe(II) binding to transferrin at pH 7.4, 10 M, which yields reduction potentials < —500 mV at pH 7.4 for the C-terminal and N-termtnal sites of human serum transferrin, and probably more negative potentials at the lower pH present in the endosome where iron is released. ... 

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