Human growth hormone time course

Figure 13.8. Effects of route and sustained release formulation on the time course of human growth hormone concentration in plasma. Shown is the average time course of human growth hormone (hGH) in plasma after intravenous (0.02mg/kg) and subcutaneous (0.1 mg/kg) administration in humans. Arrows indicate weekly subcutaneous dosing of hGH in solution. A single dose of the same protein formulated in polylactide-co-glycolide (PLG) microspheres (0.75 mg/kg) given subcutaneously sustains human growth hormone levels in plasma for at least one month.

Redmond, G.P., J.J. Bell, PS. Nichola, and J.M. Perel (1980). Effect of growth hormone on human drug metabolism time course and substrate specificity. Pediatr. Pharmacol 1, 63-70. 

FIGURE 1 Time course of protein radioiodination using the membrane blotting method. Reaction mixtures contained 0.5 mCi of Na I and 200 fig of either human growth hormone (hGH) or bovine pancreatic ribonuclease (RNase). 

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